PPARGC1A and amyotrophic lateral sclerosis: Through single nucleotide polymorphism analysis, PGC-1α and brain-specific isoforms of PGC-1α have been implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis, Huntington’s disease, and Parkinson’s disease (Soyal et al., 2012; Eschbach et al., 2013).