CAPN1 and cerebellar ataxia: While these mice do exhibit a mild form of cerebellar ataxia and impairment in synaptic plasticity and learning and memory (Zhu et al, 2015; Wang et al., 2016), the duration and severity of seizures were similar in WT and calpain-1 KO mice, indicating that the various differences we observed were not due to changes in neuronal excitability between the two genotypes.