Arf6 also regulates the cell motility of MDA-MB231 breast cancer cells through the recycling of integrin β to the cell surface (Powelka et al., 2004), suggesting the importance of the Arf6-mediated polarized transport of cell adhesion molecules, such as cadherin and integrin, during cell migration and cancer invasion. The gene discussed is ARF6; the disease is breast carcinoma.