For example, the activation of Arf6 leads to the disassembly of adherens junctions through the internalization of E-cadherin, leading to changes in cell shape and motility, a process referred to as epithelial–mesenchymal transition, during wound healing and cancer invasion (Palacios et al., 2001, 2002; Luton et al., 2004). Here, ARF6 is linked to cancer.