In the HDM‐driven asthma model, we found that the lung‐draining mediastinal LN cells of HDM‐sensitized and challenged LXRα−/−β−/− mice produced less type 2 cytokines upon ex vivo HDM restimulation as compared to LN cells from WT mice (Fig. 4B). The gene discussed is NR1H3; the disease is asthma.