TLR2 and infection: To exemplify, ESAT-6 limits macrophage responses by inhibiting signaling from Toll-like receptor-2 (TLR-2) and causes phagosomal membrane lysis, thus helping establishment of infection, while HbhA, a glycoprotein, found on M.tb surface and also in culture filtrates, is not required for initial infection, but has possible role in dissemination to extrapulmonary regions (Pethe et al., 2001; de Jonge et al., 2007; Pathak et al., 2007).