Connective tissue growth factor (CTGF/CCN2), a member of the CCN family, is a secreted protein with major roles in angiogenesis, chondrogenesis, osteogenesis, tissue repair, cancer and fibrosis (Kapoor et al. 2008; Leask 2008) Each module has specific binding affinity for certain proteins, such as fibronectin and heparin sulfate proteoglycans, extracellular signaling molecules, and cell surface proteins (Kubota and Takigawa 2015). This evidence concerns the gene CCN2 and cancer.