The key findings in the study include: (1) ANGPTL3 level was reduced in female T2DM patients compared with female non-diabetic subjects whereas ANGPTL3 level was similar between male non-diabetic and T2DM subjects; (2) after adjusting for the confounding factors, ANGPTL3 levels were positively correlated with the concentrations of cholesterol and apoA-I but negatively correlated with SAA in HDLs in non-diabetic female subjects. Here, ANGPTL3 is linked to type 2 diabetes mellitus.