By contrast, 1-SD increase of ANGPTL3 (136.1 ng/ml) associated with increase of 1.69 mg/dl cholesterol (95 % CI 0.13, 3.25, p = 0.037), 1.25 μg/mL apoA-I (95 % CI 0.88, 1.63; p < 0.0001) and decrease of 11.70 μg/L SAA (95 % CI −43.15, 66.57; p = 0.676) in HDLs of female T2DM patients (Fig. 4a–c). The gene discussed is APOA1; the disease is type 2 diabetes mellitus.