When translating into HDL function, one SD increase of ANGPTL3 related to increase of 2.11 % cholesterol efflux against HDLs in non-diabetic females (95 % CI −0.11, 4.33, p = 0.071) but decrease of 1.46 % in female T2DM patients (95 % CI −3.31, 0.39; p = 0.130) (Fig. 4d). This evidence concerns the gene ANGPTL3 and type 2 diabetes mellitus.