ANGPTL3 and type 2 diabetes mellitus: Although ANGPTL3 level was similar between male non-diabetic and T2DM subjects (428.3 ± 131.6 vs. 467.2 ± 159.3 ng/ml, p = 0.10), ANGPTL3 level was significantly reduced in female T2DM patients compared with female non-diabetic participants (558.6 ± 164.6 vs. 498.5 ± 159.9 ng/ml, p < 0.01) (Fig. 1a).