Oncogenic transcription factor AP‐1 is critical for the proliferation of cancer cells, one study showed that histone deacetylase inhibitors (HDACIs), one of anticancer agents, targeted the AP‐1 c‐Jun/Fra‐1 dimer through transcriptional inhibition of mitogen‐activated protein kinase kinase 7 (MKK7) and RAF1 proto‐oncogene serine/threonine‐protein kinase (RAF1), this resulted in inhibition of growth in neuroblastoma cells 63. This evidence concerns the gene MAP2K7 and neuroblastoma.