Previous reports have revealed that lncRNA XIST was essential for long term survival of hematopoietic stem cells [19], suppression of lncRNA XIST could markedly impair the early phase of female pluripotent stem cells induction [38], and knockdown of lncRNA XIST exerts tumor-suppressive functions in human glioblastoma stem cells [20]. Here, XIST is linked to neoplasm.