TIMP1 and glioblastoma: In general, the TIMP-1/CEN-X ratio was close to 1, but varied between 0.7 and 1.09, however, we did not have pre-defined cut-off values for TIMP-1 amplification or deletion, since, to our knowledge, TIMP-1 FISH analysis in glioblastomas or other cancers has not been described before.