At the mRNA level, IL-33 expression was higher in benign prostate tissue than primary tumours that included naïve tumours (untreated prior to surgery) or NHT tumours (treated prior to surgery (p < 0.0001; t-test), and further reduced in metastatic CRPC in a large cohort of RNA-sequencing data (Fig. 7a), suggesting an inverse correlation with disease progression. Here, IL33 is linked to neoplasm.