B2M and cancer: Moreover, a very recent large-scale genomic study of 18 types of solid human tumour biopsies (including: uterine, breast, colorectal, stomach, kidney, lung, prostate and other cancers) has highlighted loss of antigen presentation with mutations in beta-2-microglobulin, HLA-A, HLA-B and HLA-C, supports our earlier findings in lung carcinoma37, 38, 39, as a key strategy in tumour immune evasiveness40.