Collectively, genes in these signatures probably regulate cellular signaling pathways in primary and secondary breast tumors, like TGF-β, FGF, Janus kinase/signal transducers and activators of transcription (JAK-STAT), nuclear factor kappa-B (NFκB), wingless-related integration site proteins (WNT), and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) pathways in primary tumor, and TGF-β, FGF, NFκB, and PI3K pathways in metastases. The gene discussed is NFKB1; the disease is breast neoplasm.