In the same experiment, mice initiated with DMBA exposed to twice weekly topical 1.5 μM sanguinarine for 25 weeks developed an earlier onset of tumorigenesis and increase in the mean tumor number per mouse from 5 for the DMBA/TPA initiation group to 7.07 for the DMBA/TPA initiation followed by 25-week sanguinarine application group [289]. Here, PLAT is linked to neoplasm.