The canonical Wnt pathway (or Wnt/β-catenin pathway) leads to an accumulation of β-catenin in the cytoplasm that can be translocated into the nucleus and activate transcription factors.3 A recent analysis of human HCC has shown that the Wnt pathway is activated in 49% of HCC and that almost half of these had features consistent with the activation of the Wnt/β-catenin pathway.6 These data are in line with an integrated analysis of somatic mutations which revealed activating mutations of β-catenin (CTNNB1) in 33% of human HCC. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.