APC and hepatocellular carcinoma: Hypomorphic Apc mice (Apcfl/fl) were previously shown to develop HCC with activation of the Wnt/β-catenin pathway (nuclear localisation of β-catenin and activation of Wnt-related genes).26 To assess T-UCRs downstream of the Wnt pathway, we profiled ncRNA expression by microarray in the liver of Apcfl/fl and control Apc+/+ mice.