IGHE and allergic disease: L. casei strain Shirota [49], L. brevis SBC8803 [50] and a number of other LAB strains [51] have been reported for their preventive or ameliorating potential allergic diseases in ovalbumin (OA)-sensitized mouse spleenocytes by reduction of immunoglobulin E (IgE) and improvement of the balance between T helper cells type 1 (Th1) and type 2 (Th2).