Among these channels, the calcium channel and function of clamodulin was blocked or inhibited by non-opioid effects of Lop [33], while Lop acts as an opioid receptor agonist for the mu opioid receptors in the myenteric plexus large intestines and is therefore used to treat diarrhea caused by gastroenteritis or inflammatory bowel disease [34]. Here, OPRM1 is linked to gastroenteritis.