Numerous chemotherapy agents (e.g., 5-fluorouracil, Adriamycin, dacarbazine, paclitaxel) were shown to induce IL-8 expression and secretion in cancer cells [121,122,123] as a mechanism of resistance; targeting IL-8 signaling may increase the sensitivity of cancer cells to conventional chemotherapy and novel treatment strategies. Here, CXCL8 is linked to cancer.