CCND1 and familial pancreatic carcinoma: Study of pancreatic cancer in nude mice has shown that curcumin can suppress pancreatic cancer cell proliferation and angiogenesis by inhibiting NF-ĸB-regulated gene products such as cyclin D1, cmyc, Bcl-2, Bcl-xL, and apoptosis protein-1, COX-2, MMP, and vascular endothelial growth factor (VEGF) [18].