Adding further support to the role of TRPV3 in skin physiology and pathology, a TRPV3 gain-of-function G573S/C mutation was identified to underlie the spontaneously hairless, dermatitis phenotype of two rodent strains, DS-Nh mice and WBN/kob-HT rats, used as animal models of atopy [31,58,59]. Here, TRPV3 is linked to dermatitis.