TRPM2 and myocardial infarction: Likewise, infarct sizes were significantly larger in the heart of Trpm2 KO mice carrying WT neutrophils compared to the heart of Trpm2 KO mice with TRPM2-deficient neutrophils, suggesting that the activation of neutrophil TRPM2 during reperfusion has an important role in the development of myocardial infarction.