Interestingly, research has demonstrated that dyslipidemia and inflammation may link reduced bone mineral density and vascular calcification: it has been reported that patients with low bone density have more pronounced atherosclerotic plaque calcification [136,137], and different preclinical studies have suggested that hyperlipidemia promotes both arterial calcification and bone loss in the ApoE−/− model [138,139,140]. Here, APOE is linked to metabolic syndrome.