APOE and myocardial infarction: Furthermore, it has been reported that ApoE−/−Fbn1C1039G+/− mice seem to be associated with a more unstable plaque phenotype compared to ApoE−/− mice because they develop acute plaque rupture, with subsequent myocardial infarction, neurological symptoms (head tilt, disorientation and motor disturbances), and sudden death.