In humans, the expression of E-selectin is limited to endothelial cells on the surface of fibrous and lipid-rich plaques [153], whereas in the aortas of normal chow-fed ApoE−/− mice, E-selectin was not expressed on endothelial cells in regions predisposed to atherosclerosis or in early and advanced plaques. The gene discussed is SELE; the disease is atherosclerosis.