VEGFA and lung carcinoma: In the above mentioned study, lung cancer-derived brain metastases expressed vascular endothelial growth factor A (VEGF-A) and inhibition of VEGF-A by bevacizumab prevented angiogenesis and induced dormancy of the micrometastasis [67] suggesting that VEGF-A is a key signaling molecule in early formation of the perivascular niche of metastatic lung cancer cells.