Six proteins were recognized by autoantibodies from half of the patients with SSc and none of the controls: Fibroblast Growth Factor 2 (FGF2), Allograft Inflammatory Factor 1 (AIF1), Ephrin Type-B receptor 2 (EphB2), Dual specificity protein kinase CLK1, Three prime Histone mRNA EXonuclease 1 (THEX1) and Ankyrin repeat and Sterile alpha motif domain containing 6 (ANKS6). Here, ANKS6 is linked to systemic sclerosis.