EPHB2 and systemic sclerosis: Nevertheless, when patients were classified according to classical SSc- specific AAb status (ATApos, ACApos or ATA/ACAneg), those without classical SSc-AAb (ACA/ATAneg) were the one who had more often anti-EphB2 AAb (44%) and with the highest Absorbance levels (P<0.0001, Fig 2A).