The FoxO3a protein is reported to be an important transcription factor and is associated with several essential cellular functions including cell proliferation, apoptosis, metabolism, stress resistance and longevity in several cell types [47, 48].Tao et al. reported that FoxO3 overexpression improves hypercholesterolemia in obsess mouse models. Here, FOXO3 is linked to familial hypercholesterolemia.