It is well documented that epigenomic chromatin modifications are critical in determining the ZEB1 transcription,12 and that miRNAs are involved in regulating the ZEB1 transcripts.50 We have yet to understand what types of genome/epigenome statuses of cancer cells, as well as the microenvironments, are involved in the apparently non-linear processes inducing the ZEB1-EPB41L5 axis. This evidence concerns the gene EPB41L5 and cancer.