Therefore, although the high expression of ZEB1 and EPB41L5 appears to occur among certain populations of primary breast tumors bearing TP53 mutations, these results suggested that the loss of normal-p53 might not be a major cause inducing the ZEB1-EPB41L5 axis and that induction of this axis may frequently occur even in the presence of normal-p53. The gene discussed is TP53; the disease is breast neoplasm.