EPB41L5 and breast cancer: EPB41L5 binds to paxillin,27 which is an integral component of the invadopodia of breast cancer cells.30 AMAP1 is also an integral component of invadopodia and binds to paxillin.21 We found that AMAP1 is co-precipitated with anti-EPB41L5 from MDA-MB-231 cell lysates (Figure 1b).