Likewise, although the expression of SNAI1 has been shown to induce ZEB134 and to be critical to the malignancy of certain populations of primary breast cancers,49 SNAI1 did not necessarily induce ZEB1. Furthermore, although we observed that loss of normal-p53 induces the ZEB1-EPB41L5 axis in MDA-MB-231 cells, loss of normal-p53 does not always induce the ZEB1-EPB41L5 axis among different preparations of HMLE cells. This evidence concerns the gene EPB41L5 and breast cancer.