This was paralleled by an increase in eNOS, which is involved in vessel dilation (2.2-fold, Fig 1G), and a strong tendency of ICAM-1 increase (2.5-fold, Fig 1H) in HFD as well as in human T2D islets (Fig 1I), a marker known to be associated with leukocyte infiltration. This evidence concerns the gene NOS3 and type 2 diabetes mellitus.