In a chronic social stress (CSS) mediated rodent model of PPD [44, 45], OXT gene expression is reduced in the hypothalamus and amygdala of stress exposed rats that exhibit depressed maternal care, impaired lactation, and increased anxiety [46, 47], and OXT levels in the amygdala are correlated with maternal care [48]. This evidence concerns the gene OXT and progressive pseudorheumatoid arthropathy of childhood.