NLRC4 and infection: Dissection of the contributions of the cellular compartments has revealed that cecum-derived E-cadherin+ intestinal epithelial cells (IEC) express high amounts of ASC adaptor, and Nlrp3 and Nlrc4 activation are both critical for protection against C. rodentium early in the course of infection (Nordlander et al., 2014; Song-Zhao et al., 2014).