However, increases in both MAT and circulating adiponectin also occur in many other diverse conditions, including aging, estrogen deficiency, type I diabetes, and in response to pharmacological agents such as TZDs, glucocorticoids and fibroblast growth factor-21 (FGF21) (Fig. 5).8,25,36,69-73. This evidence concerns the gene FGF21 and type 1 diabetes mellitus.