Metabolomics revealed that vitamin C causes pentose phosphate pathway metabolites and glycolytic intermediates located up-stream of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) to increase in KRAS and BRAF mutated colorectal cancer cells, whereas metabolites down-stream of GAPDH were decreased (Yun et al. 2015). This evidence concerns the gene BRAF and colorectal cancer.