The chronic hyperglycemia of diabetes may induce VEGF up-regulation via the PLA2/COX-2/VEGF-A pathway9, 10, the PKCbeta/HuR/VEGF pathway11, the ERK1/2/COX-2/PGE2 pathway12 and the TLR2 and TLR4 pathway13. This evidence concerns the gene VEGFA and diabetes mellitus.