In M. marinum infected-zebrafish, the targeting of VEGFR signaling increases the efficacy of the first-line antitubercular drug rifampicin10, and in M. tuberculosis infected-rabbits, treatment with an anti-VEGF antibody normalizes the vasculature of granulomas, leading to the penetration of small molecules54. The gene discussed is VEGFA; the disease is Granuloma.