VEGFA and peripheral nerve injury: Taken together our observations of: increased spinal splicing factor expression, increased spinal pro-nociceptive VEGF-A165a but unchanged VEGF-A165b expression, and blockade of pain behavior and VEGF-A expression changes by SPRK1 inhibition, suggest that exogenous and endogenous VEGF-A isoforms modulate spinal nociceptive processing in naïve animals and after peripheral nerve injury.