In lieu of the above results, we performed subsequent experiments in five selected, representative PDA cells lines namely MIA PaCa2 and PANC-1 (DNA repair proficient, DDR-P) and Capan-1, Hs 766T and PL11 (DNA repair deficient, DDR-D) (Table 1 and Supplementary Table S2), all of which also have deficient p53 status. This evidence concerns the gene TP53 and Patent ductus arteriosus.