In order to investigate whether LARP4 contributes to cell elongation in 3D as well as on 2D substrata, a 3D morphology based assay was carried out using MDA‐MB‐231 cells embedded in Matrigel [Colomba and Ridley, 2014], which is a cell‐derived extracellular matrix used to mimic the environment of tumours [Gill and West, 2014]. This evidence concerns the gene LARP4 and neoplasm.