However, it has recently been proposed that individual cancers have latent or rare driver mutations that contribute to cancer progression [D'Antonio and Ciccarelli, 2013; Nussinov and Tsai, 2015] We speculate that the LARP4 mutants which resulted in significant changes in cancer cell morphology could be rare driver mutations, contributing to tumour progression in some human cancers, in concert with known driver mutations. The gene discussed is LARP4; the disease is neoplasm.