The main objective of current antiviral therapy was to block the progression of chronic liver injury and reduce the portion of liver cirrhosis among the CHB patients14, 15; however, between 10% to 37% of CHB patients with normal ALT already having significant necroinflammation and fibrosis16, 17, thus for these CHB patients with normal ALT, liver cirrhosis may has been developed at the initial antiviral treatment, and severe liver necroinflammation in these patients who have developed liver cirrhosis whether can be mitigated by antiviral treatment still remains unknown. This evidence concerns the gene GPT and medical procedure.