TP53 and cancer: In our data, 48/104 inversion break points disrupted or fused genes (Supplementary Data 5), with one forming a driver mutation through disruption of TP53. For the mutational signature of small deletions that we observe, we estimate that the median excess of indels in the radiation-induced cancers sequenced here is 201 indels per genome (linear mixed effects model, s.d. 348 indels).