Moreover, a decreased risk of astrocytoma subtype associated with the C alleles of CHAF1A rs243341 and rs2992 as well as the T allele of XRCC1 rs25487 involved in DNA repair pathway was detected (pDOM=0.040, pDOM=0.049, and pDOM=0.033, respectively). Here, CHAF1A is linked to astrocytoma (excluding glioblastoma).