PROM1 and colorectal carcinoma: The expression level of EpCAM (Membrane), E-cadherin, MRP, CD133 and Cyclin D1 were significantly upregulated in primary CRC foci compared with the corresponding lymph-node metastatic foci, whereas CD44v6 was downregulated in primary CRC foci (Figure 1A and 1B, p < 0.05).