TP53 and malignant colon neoplasm: The EMT marker induction by H2O2 was observed in the anti-oxidant NAC-sensitive manner both in HCT116(p53 wt) and HCT116(p53 null) as well as HT29(p53 mt) colon cancer cells, indicating that EMT induction by ROS occurred independent of p53 activity in colon cancer cell lines (Figure 1C).