The expression of Cyclin A, CDK2,p-CDK2, β-catenin, p-STAT3 (Tyr705), p-STAT5 (Tyr694) and proline-rich protein 11 (PRR11) was downregulated, the expression of Axin and adenomatous polyposis coli (APC) was upregulated; and the expression of STAT3 and STAT5 was not significantly change (Figure 3B, 3C), suggesting that cZNF292 silencing represses tumor tube formation through regulating cell cycle by Wnt/β-catenin signaling pathway. The gene discussed is APC; the disease is neoplasm.