AXIN1 and neoplasm: Axin is known to be the tumor suppressor gene was associated with the other colorectal tumour suppressor APC, their central function of axin is to degradation of β-catenin, which is a downstream signaling molecule of Wnt/β-catenin signaling pathway, which regulates many biological functions in tumor cells, to prevent the activation of Wnt/β-catenin signaling pathway [17].