This analysis revealed several cytokines that were associated not only with migration and invasion, but also with growth and angiogenesis in gliomas, such as MCP-4 [30], IL-6 [16], IL-19 [31], TWEAK [32], VEGF-C [33], GRO [34], LIF [35], IGF-1 SR, IGFBP-3 [36] and IGFBP7 [37, 38] (Figure 4A and 4B). The gene discussed is IGFBP3; the disease is central nervous system cancer.