Considering the upregulation of hnRNP A1 in various tumors and its roles in cancer development by promoting tumor invasion and so on (Pino et al., 2003; Ushigome et al., 2005; Carpenter et al., 2006; Boukakis et al., 2010; Zhou et al., 2013), hnRNP A1 caused escaping from Ras OIS and promoting cell transformation and tumor development in nude mice in SIRT1‐dependent manner provides novel explanation for its role in tumorigenesis. This evidence concerns the gene SIRT1 and cancer.