HTT and neurodegenerative disease: Furthermore, degradation of numerous proteins linked to neurodegenerative diseases such as Huntingtin (htt; t1⁄2 ≈ 3.7 days) α‐synuclein (Snca; t1⁄2 ≈ 2.4 days), Tau (Mapt; t1⁄2 > 20 days), and TDP‐43 (Tardbp; t1⁄2 ≈ 5.4 days) was not significantly retarded by proteasomal inhibitors.