MSCs are considered as a suitable cell source for the treatment of periodontitis not only for their capacity to regenerate different types of tissues, but also for their paracrine potential, secreting large quantities of growth factors and anti-inflammatory cytokines such as TGF-β and interleukin (IL)-10 which play important roles in systemic and local immunomodulation [34, 35]. This evidence concerns the gene IL10 and periodontitis.