According to KEGG enrichment analysis, the down-regulated DEGs were significantly enriched in 6 pathways, such as arrhythmogenic right ventricular cardiomyopathy (ARVC) (e.g. ACTN4, CTNNA1 and ITGB5), regulation of actin cytoskeleton (e.g. ACTN4, MYL9 and ITGB5) and complement and coagulation cascades (e.g. C1R and C1S). The gene discussed is ACTN4; the disease is Arrhythmogenic right ventricular dysplasia.