Some DEGs related to cytoskeleton organization (e.g. MTSS1, ACTN4 and CALD1), cardiomyopathy (e.g. ITGB5) and immune response (e.g. C1S and C1R), as well as some regulators (e.g. LEF1 and hsa-miR-33a) might play pivotal roles in the progression of DN. The gene discussed is ACTN4; the disease is cardiomyopathy.