ITGB5 and diabetic cardiomyopathy: Furthermore, a series of downregulated DEGs were discovered to be enriched in the pathways of arrhythmogenic right ventricular cardiomyopathy and hypertrophic cardiomyopathy in our study, such as ITGB5. Diabetic cardiomyopathy is a frequent event in diabetic patients due to hyperglycemia [30].