In parallel, defects in IFN-I signaling have been demonstrated during productive HIV infection including the inhibition of IRF3 by HIV Vpr [15], disruption of MHC-I by HIV Nef [16], degradation of RIG-I by HIV protease [17], and Tat-mediated impairment of PKR [18]. This evidence concerns the gene EIF2AK2 and HIV infectious disease.