In a multivariable analysis adjusting for age (categories: < 40, 40–70, > 70 years), otitis or sinusitis, diabetes mellitus, neck stiffness, score on GOS, CSF leukocyte (<1000 cells/mm3), CSF protein (g/l), thrombocyte count (< 150 × 1012/L), C-reactive protein (mg/l) and L. monocytogenes, the use of immunosuppressive medication was no longer associated with death (OR 0.94, 95 % CI 0.46–1.93, P = 0.86). The gene discussed is CRP; the disease is sinusitis.