Another group generated iMSCs through TGF-β-pathway inhibition and medium changes; those iMSCs, surprisingly, did less to promote cancer than BM-MSCs, appearing to express and produce lower amounts of several of the inflammatory and differentiation factors (particularly TGF-β receptor-2 and, interestingly, hyaluronan (HA)) when cultured with various types of cancer cells [74]. This evidence concerns the gene TGFB1 and cancer.