To explore whether POLQ deregulation in cancer could be part of a global deregulation of genes involved in the response of replicative stress, we thought to go back to our previously reported real-time PCR data related to DNA samples from breast, colorectal or lung cancer patients (Allera-Moreau et al., 2012; Lemée et al., 2010; Pillaire et al., 2010), and address whether the expression of POLQ was correlated with the expression of other genes. This evidence concerns the gene POLQ and cancer.